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Weight Control Drugs

It all comes down to calories

Whether you want to lose five holiday pounds or a serious 1-5-0, you are not alone. There are lots of diet aids out there. But in taking aim against fat, don't expect a magic bullet. Even the labels on over-the-counter diet drugs encourage moderate, healthy eating and exercise in order to lose weight. In the end, it's the calories consumed, minus the calories expended, that add up to successful weight loss. Diet drugs can help jump-start your weight-loss program. Just don't rely on them to give you discipline -- you have to do that part yourself.


If You Are Using Diet Drugs to Lose Weight, Follow These Directives

  • Do not use diet aids for more than three months.
  • Even small doses of phenylpropanolamine hydrochloride (PPA) can cause increased blood pressure by constricting your blood vessels and increasing your heart rate. Larger doses may lead to anxiety, insomnia, cardiac and circulatory distress, and headaches.
  • Consult your doctor before embarking on any weight-loss regimen and before using these stimulants (especially PPA), particularly if you have any of the following conditions: high blood pressure, diabetes, or heart or thyroid disease.
  • PPA is a controversial drug. Some studies have shown it to be safe and effective for up to 16 weeks, while others have revealed it may cause severe health problems.
  • If you become nervous, dizzy, or have trouble sleeping while on these drugs, stop taking them and consult your doctor.
Some More Information To Digest

Due to statistically unsound studies on the effectiveness of benzocaine diet aids when compared to placebos, the FDA has advised manufacturers that better-designed studies are needed. As a result, many manufacturers have removed benzocaine from their weight-loss products.

Some popular diets are not only ineffective fads, they can be nutritionally unbalanced and dangerous if followed for extensive lengths of time. Avoid diets based on single food groups or that promise results without genuine scientific evidence.

Be equally careful of "natural" ingredients; they do not undergo review for safety and effectiveness. Serious adverse reactions have been associated with ma huang (a botanical source of ephedrine), guar gum, and weight-loss teas.


Stimulants

Stimulants are substances which get the body ready for the so-called "fight or flight" response. As diet aids, it's not exactly clear how stimulants work, but they are thought to activate the central nervous system to reduce food intake. The stimulant used in over-the-counter diet aids is phenylpropranolamine, which is also a common decongestant in cold medications.

Anesthetics

Topical anesthetics -- namely benzocaine -- have an unclear mechanism of action when used as diet aids. They may work by decreasing the ability to detect degrees of sweetness by taste perception. However, since there are no well-designed studies showing benzocaine's efficacy, the FDA has prompted many manufacturers to withdraw benzocaine from their weight-loss products.

Stimulants
Ingredient
Description
Phenylpropanolamine?Its mechanism as an appetite suppressant is unknown, but it can be effective and nonaddictive.
Anesthetics
Ingredient
Description
Benzocaine?Thought to work by deadening taste buds and thereby suppressing appetite. Safe.

Recommended Dosage

Phenylpropanolamine
DrugAdults & Children Over Age 12Max. DailyChildren Ages 6 to 12Max. DailyChildren Under Age 6Max. Daily
Phenylpropanolamine25 mg three times a day, 30 mins. before meals; or 75 mg once daily, depending on specific product75 mgNot recommendedNot recommended
Benzocaine
DrugAdults & Children Over Age 12Max. DailyChildren Ages 6 to 12Max. DailyChildren Under Age 6Max Daily
Benzocaine6 to 15 mg in candy, gum, or pill; before meals.45 mgNot recommendedNot recommended

Warnings

Stimulants

Consult a physician before use or do not use if you have:
  • Diabetes
  • Allergy to phenylpropanolamine
  • Enlarged prostate
  • Heart disease
  • High blood pressure
  • Thyroid disease
Or if you:
  • Are pregnant or nursing
  • Are a senior; you may require a lower dosage
  • Are administering to a child under age 6
  • Use a larger dose than recommended
Or if you are taking:
  • Antihypertensives, such as:
    • Enalapril (Vasotec): may decrease enalapril's antihypertensive effects
    • Nifedipine (Adalat): may decrease nifedipine's antihypertensive effects
    • Atenolol (Tenormin) or Metoprolol (Lopressor): may decrease antihypertensive effects
  • Guanethidine (Ismelin): may decrease guanethidine effects
  • Indomethacin (Indocin): may cause a serious and sudden increase in blood pressure
  • Monoamine oxidase inhibitors (a class of antidepressants), such as:
    • Phenelzine (Nardil): increases phenelzine effect and toxicity. May cause a dangerous increase in blood pressure
    • Tranylcypromine (Parnate): increases tranylcypromine effect and toxicity. May cause a dangerous increase in blood pressure
Topical anesthetics

Consult a physician before use or do not use if you have:
  • Allergy to sulfites (a possible component of the medication)
  • Allergy to tartrazine (a possible component of the medication)
  • Heart disease
  • Liver impairment
  • Blood disorders (methemoglobinemia)
Or if you:
  • Are pregnant or nursing
  • Are treating a child under age 12
Common Side Effects

Stimulant
  • Increased blood pressure
  • Rapid heartbeat
Topical anesthetic
  • None anticipated
Infrequent to Rare Side Effects

Stimulant
  • Dizziness
  • Dry mouth
  • Insomnia
  • Nausea
  • Restlessness
Topical anesthetic
  • Allergic reaction
  • Burning sensation
  • Itching
  • Stinging sensation
Effects of Overdose

Stimulant
  • Excitation
  • Rapid and irregular heartbeat or chest pain
  • Seizures
  • Vomiting
Topical anesthetic
  • Excitation
  • Low blood pressure
  • Seizures
  • Slow heartbeat
What to Do in Case of Overdose

  • If you suspect that you or someone you know has taken an overdose of this medication, immediately STOP USING THE MEDICATION and SEEK MEDICAL HELP.

Websites, Organizations & Manufacturers
Sources & Further Reading

Government Sources

1. Food & Drug Administration.Federal Register 8/8/91.
2. Food & Drug Administration.Federal Register 8/16/77.
Books

1. Covington, TR et al. Handbook of Non-Prescription Drugs, Eleventh Ed. American Pharmaceutical Assoc. Washington, DC 1996.
2. Kastrup EK et al. Drug Facts and Comparisons. Facts and Comparisons.
3. Inlander, CB and Slamans, S.The Over-the-Counter Doctor. Cader Books. New York, NY 1997.
Find more books on health and wellness at barnesandnoble.com.

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