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Vitamin K

Essential for blood clotting

Without enough vitamin K in your blood, a small skin cut could become a major bleeder. Fortunately, most of us have plenty of this essential vitamin to make our blood clot properly. In fact, K was taken from the Danish word "koagulation" which, of course, means coagulation.

Vitamin K is a fat-soluble vitamin. Besides preventing abnormal bleeding, it helps calcium form bones.

About half of your intake of vitamin K comes from what you eat in vegetables like raw cauliflower and spinach; the other half is produced by naturally occurring bacteria in your intestines. Because of this, you're unlikely to be deficient.

Quick Facts About Vitamin K
  • RDA is 65 to 80 micrograms (mcg) per day for healthy adults.
  • Some foods rich in vitamin K are green leafy vegetables (broccoli, Brussels sprouts, cabbage, cauliflower, spinach, and turnip greens), milk, fish liver oil, green tea, and soybean oil.
  • Some signs of vitamin K deficiency are easy bruising, impaired blood clotting, and frequent nosebleeds.

You May Need More Vitamin K if You Have (or Have Had)
  • Chronic malnutrition
  • Impaired fat absorption
  • Intestinal damage
  • Recent injury or severe burns
  • Recent surgery
  • Crohn's disease or ulcerative colitis
  • Liver impairment
Or if You're
  • Over age 55
  • Under excessive stress
  • A premature newborn
  • Taking antibiotics that may inhibit the function of vitamin K-producing bacteria in your intestines
  • Taking medications that inhibit fat absorption
  • Suffering from cystic fibrosis because of fat absorption problems
What Works Best -- and Worst -- with Vitamin K
  • Vitamin K deficiency may cause vitamin E to inhibit your blood-clotting ability.
  • Dietary fat enhances vitamin K absorption.
  • Calcium and vitamin K help bone formation.
Forms Available
  • Individual supplements as tablets
  • Injectable forms administered by your clinician
  • Supplements are not usually necessary since your diet and intestinal bacteria meet your normal requirements for vitamin K; besides, most supplements don't contain vitamin K.

Chemical Forms
  • Vitamin K-1 (phylloquinone)
  • Vitamin K-2 (menaquinone)
  • Vitamin K-3 (menadione)
Comments On Vitamin K
  • Vitamin K-1 (phylloquinone) comes from plants.
  • Vitamin K-2 (menaquinone) comes from intestinal bacteria.
  • The synthetic form, vitamin K-3 (menadione) is the most active form of the three.
  • All forms of vitamin K are converted into menaquinone, the biologically active form.
  • Vitamin K helps produce an important clotting factor called prothrombin.
  • Vitamin K is not generally available in most multivitamins because most people meet their requirements from food and their intestinal bacteria.

Known Benefits of Vitamin K
  • Essential for proper growth and development of bones.
  • Prevents hemorrhaging in infants.
  • Promotes normal blood clotting.
Unproven Claims
  • Delays onset of osteoporosis.
  • Enhances treatment of cancer with radiation therapy.
  • May reduce risk of developing osteoporosis.
Vitamin K May Prevent These Signs of Deficiency
  • Abnormal growth and development in infants
  • Abnormal blood clotting hemorrhagic diseases
  • Bruising easily
  • Frequent nosebleeds
Recommended Dosage Range for Vitamin K
  • Our pharmacists suggest that healthy adults may take 65 to 80 mcg to supplement a well-balanced diet.
  • RDA values were set as the minimum needed to offset deficiency or disease, not as an actual value needed for optimum health.
  • In the United States, the average consumption of vitamin K is 80 to 150 mcg per day.
  • If taking more than 1,000 mcg per day of vitamin K, consult your physician.
  • Consult your physician before starting any high-dose supplement regimen.
Dietary Sources

Food Tips
  • Though more research needs to be done, vitamin K appears to be stable to light, heat, and air. So, you can cook and store food with little worry about losing vitamin K.
  • Leafy green vegetables are the best source of vitamin K.
Foods High in KServing SizeAmount of KUnits
Beef liver
Broccoli, raw
Cabbage, raw
Cauliflower, raw
Soybean oil
Spinach, raw
Turnip greens, raw
Wheat germ
3 ounces
1/2 cup
1/2 cup
1/2 cup
1 tablespoon
1/2 cup
1/2 cup
1 ounce
89
58
52
96
76
74
182
10
mcg
mcg
mcg
mcg
mcg
mcg
mcg
mcg

When and How to Take Vitamin K
  • Tablets should be swallowed whole with a glass of water.
  • Take with food or after meals to enhance absorption.
What Not to Take with Vitamin K
  • Mineral oil may lead to a deficiency in vitamin K.
  • Excessive calcium doses or a calcium to phosphorus ratio above 2-to-1 interferes with vitamin K synthesis and/or absorption.
  • Vitamin K deficiency may be exaggerated by high levels of vitamin E. This can result in hemorrhaging.
  • Excessive doses of vitamin A inhibit vitamin K.
Storage
  • Keep vitamin K in a cool, dry place away from direct sunlight and air.
  • Don't freeze vitamin K.
  • Don't store vitamin K in your bathroom medicine cabinet. Heat and moisture may make it less effective.
  • Store safely out of children's reach.
Recommended Daily Allowance

AGE/GROUPRDA
Infants
0 to 6 months
6 to 12 months
1 to 3 years
4 to 6 years
7 to 10 years
Males
11 to 14 years
15 to 18 years
19 to 24 years
25 to 50 years
51+ years
Females
11 to 14 years
15 to 18 years
19 to 24 years
25 to 50 years
51+ years
Pregnant
Lactating
1 to 6 months
6 to 12 months
mcg (micrograms)
5
10
15
20
30

45
65
70
80
80

45
55
60
65
65
65

65
65

Warnings

Consult a physician before use or do not use vitamin K if:
  • You're about to start a high dose supplement program.
May Have Interactions with the Following:
  • Androgens: in test animals decrease prothrombin levels.
  • Antacids containing aluminum: decrease absorption of fat soluble vitamins A, D, E, and K.
  • Cholesterol lowering drugs: especially bile sequestering agents can cause deficiency of fat soluble vitamins, including vitamin K.
  • Estrogens: in test animals increase prothrombin levels.
  • Laxatives: prolonged use of mineral oil, phenolphthalein and DSS can cause deficiency of fat soluble vitamins, including vitamin K.
  • Long-term IV feeding: requires vitamin K supplementation.
  • Oral antibacterials: especially second- and third-generation cephalopsorins kill intestinal bacterial that synthesize vitamin K, and can cause delayed blood clotting.
  • Primadone (mysoline): may lower plasma level of vitamin K.
  • Vitamin A: in high doses adversely influences vitamin K function.
  • Vitamin E: in high doses might exacerbate a borderline deficiency of vitamin K.
  • Warfarin (coumadin): interferes with vitamin K utilization.
Side Effects
  • Counteracts blood-thinning drugs.
  • Only injected menadione is associated with more serious side effects and this is only available from a healthcare provider.
Signs of Overdose

  • None anticipated.
  • Oral forms of vitamin K have not been associated with overdose symptoms.
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