The Consumer Guide to Chitin/Chitosan

In this guide...
  Benefits and Uses
  Recent findings:
  Do Scientists Know How It Works?
  Food sources:
  Types of products:
  Safety:
  Books:
  References
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Chitin (pronounced kite-in) and chitosan (kite-o-san) are fibers derived from marine animals. Chitin is a polysaccharide-a string of sugar molecules-that naturally occurs in the hard outer shell of insects, shellfish such as crab, lobster, and shrimp, and marine coral. Chitin is chemically similar to cellulose and starch, the abundant plant fibers. It is used to make various other substances, including chitosan, which is derived from chitin by heating it with a chemical solution. Chitosan, has the advantage of being more soluble in water compared to chitin Scientists have intensively investigated the properties and uses of chitin, chitosan, and their derivatives-collectively they are the subjects of approximately 1,000 scientific studies and hundreds of patents. Most of this attention originated in Asia but in recent decades Westerners have begun to take chitin and chitosan as nutritional supplements and major corporations have jumped on the research bandwagon

Benefits and Uses:
Chitosan has the unique ability to dissolve and grab ahold of fats and cholesterol in the stomach. Because Chitosan is mostly indigestible, it can then prevent these lipids from being absorbed in the digestive tract. This can ultimately promote safe weight-loss and a reduction in cholesterol levels. chitin and chitosan are also now being taken like acidophilus, FOS, and other supplements to speed the transit of foods through the digestive system and to promote the growth of beneficial live bacteria in the intestines. They can thereby improve digestion, cleanse the colon, and prevent diarrhea and constipation. More speculatively, chitin and chitosan may protect the liver, prevent or reduce tumors, heal ulcers, regulate blood pressure, and boost immune response. Chitin and chitosan have numerous industrial uses, in wastewater treatment; surgical sutures, wound dressings, and other medical applications; as a fertilizer and in animal feed; and in moisturizers, bath lotions, and other body care products.

Recent findings:
Japanese researchers found that four weeks of
chitosan supplementation reduced total blood cholesterol and caused a number of other beneficial effects on patients with kidney failure. Chinese researchers recently confirmed antioxidant properties in chitin and chitosan compounds. A study published in a Polish medical journal determined that a biological dressing made from a combination of human placenta and chitosan was comfortable and efficient, and promoted the process of healing.

Do Scientists Know How It Works?
Chitosan's primary mechanism of action is well established. It is known to differ from other polysaccharides in that it has a strong positive charge that lets it chemically bond with certain compounds, especially fats and cholesterol. Other mechanisms of action in the body are still being investigated. The ability to bond with fats and other substances is also the reason for many of chitin and chitosan's industrial uses. For example, spread on water chitin absorbs grease and other potentially toxic substances, which is why it is prominent in wastewater treatment processes.

Food sources:
Small amounts of
chitin are found in mushrooms (where the substance was first identified in 1811) and yeast. The chitin and chitosan used to make nutritional supplements are derived from sources, like crab shells and lobster shells, that are not eaten as foods.

Types of products:
The most popular products are capsules and tablets ranging in size from 500 to 1,000 mg.

Safety:
Chitin and chitosan are nontoxic and free of side effects, although they share the same precautions for safe use that apply to other types of fiber. Thus, to prevent intestinal blockage they should always be taken with plenty of water. Also, these supplements can bind with fat-based vitamins, such as vitamin E, and certain drugs, thus reducing these substances' absorption and effectiveness. (Take chitin and chitosan separately from vitamins; before a high-fat or high-calorie meal is a common time. And check with your doctor if you are taking medication.) Although chitin and chitosan are considered non-allergenic, people with shellfish allergies should not take them, nor should pregnant or breastfeeding women.

References

  • Jing, S.B., et al., "Effect of chitosan on renal function in patients with chronic renal failure," J Pharm Pharmacol (1997), 49(7):721-23
  • Xue, C., et al., "Antioxidative activities of several marine polysaccharides evaluated in a phosphatidylcholine-liposomal suspension and organic solvents," Biosci Biotechnol Biochem (1998), 62(2):206-09
  • Drenda, P., et al., "[Evaluation of the usefulness of dressings made from chitosan and lyophilized human placenta on wound healing]," Wiad Lek (1997), 50 Su 1 Pt 2:252-56

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